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These limitations have motivated researchers to investigate alternative delivery methods that can bypass the BBB while ensuring sufficient patient compliance, preferably avoiding invasive routes like injections

Interestingly, as shown in our transcriptome data, in addition to the pronounced enrichment of genes associated with JA signaling in systemic leaf tissues after GSH treatment, genes responsive to other defense phytohormones such as ethylene and salicylic acid, which are responsible for plant resistance to pathogen infection, are also highly upregulated (Supplementary Data 1), implying that GSH might also act as a signaling molecule to activate the plant systemic immune response

& Ramesh, S

It is unclear whether the discrepant impacts of resistance versus aerobic exercise on memory-related tasks in humans results from activation of different physiological pathways, individual differences in response to exercise, or different cognitive testing approaches used across studies

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