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10.1172/JCI116842

Mol Cancer Res 6(10):15211533 Cho KH et al (2014) A ROS/STAT3/HIF-1 a signaling cascade mediates EGF-induced TWIST1 expression and prostate cancer cell invasion

These temporal patterns highlight a critical window for intervention between 3-6 months post-infection, when IBS symptoms often become established yet remain potentially reversible before chronic remodeling occurs