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HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis

In sperm, mitochondria nestle in the midpiece and energize motility

Intracellularly, CHAC1 enzymatically degrades GSH into 5-oxoproline and Cys-Gly, acting as a pro-ferroptotic execution signal by accelerating GSH exhaustion 151

A unique feature is that BRAF V600E -mutated hemispheric pLGG tend to progress from low to high grade tumors at which point they become difficult to manage and exhibit therapy resistance to BRAF inhibition ( V600E pLGG and the progression from low- to high-grade are not available, which is why little is known about their biology and the underlying mechanisms of progression