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Since 2-O-methylation is eliminated in Dmhen1 mutants, average piRNA length and abundance are decreased, suggesting that this modification aids in shielding mature piRNAs from deterioration

Head Neck 43(1):E7-E12, 2021

Furthermore, dysregulation of antioxidant defense may aggravate iron accumulation, as iron catalyzes elevated free radical generation in oxidative environments [197, 198]

However, the oversimplified linear paradigm that equates neurodegeneration with harm fails to explain the complex phenomena observed in this field

, L-: , 2015 WebMD Masato Inazu, Teruhiko Matsumiya, Physiological functions of carnitine and carnitine transporters in the central nervous system, 2008 National Institutes of Health, Carnitine