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NE neurons originate in the locus coeruleus (LC) of the brain and extend their axons through different regions such as the CNS cortex, hypothalamus, amygdala, cerebellum, and spinal cord to reach primary nerve centers or other neurons (Newport et al., 2015)

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These MVs carry not only CD38, but also CD39, CD73 and CD203a ectoenzymes, inhibitory complement receptors CD55 and CD59, the checkpoint inhibitor PD-L1, and the myeloma differentiation marker CD138 ( In addition to reducing surface CD38, antibody-induced modulation may involve two other mechanisms: i) signal transduction that activates intracellular signaling pathways, and ii) cargo transfer