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investigated two of Chiles southernmost berries, murtha and calamansi, and identified them as fruits with high ORAC values and natural antioxidant properties ( 3.3.2 TRAP Marge Kartau et al

45 Moreover, cellular senescence is defined as permanent growth arrest caused by endogenous and exogenous stress

IMC3 demonstrates lactate-fueled respiration and pentose phosphate pathway activation, contributing to redox balance, DNA repair, and resistance to targeted therapies such as anti-BRAF or KRAS inhibitors

Subsequently, glutamate can be catalyzed by transaminases such as glutamate-oxaloacetate transaminase (GOT), glutamate-pyruvate transaminase (GPT), or glutamate dehydrogenase (GLUD), to produce -ketoglutarate, which enters the TCA cycle

Acknowledgements We thank Jonathan Coloff and Samuel McBrayer for their feedback and discussions