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The main mechanisms include stimulating the expression of follicle-related growth factors, dilating scalp blood vessels and improving microcirculation, boosting the differentiation and proliferation of hair follicle epithelial cells, and activating the Wnt/-Catenin signaling pathway and its key proteins (Scheme 2)

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Picard B, Lefaucheur L, Berri CC, Duclos MJ

Splitting ALA into smaller doses may help reduce gastrointestinal side effects, especially at higher intakes.43 Taking ALA with food can also improve tolerability though some studies suggest it may slightly reduce absorption.13 44 That tradeoff may be worth it for users sensitive to GI effects, particularly when taking ALA long-term

We postulate that boosting mitochondrial metabolism might be a potential therapeutic strategy to induce antidepressant effects