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In conclusion, ultra-high-dose methylcobalamin was not found to be significantly superior to placebo

As CEO Todd Zavodnick put it: A lot of patients are being undertreated and we believe this market is massive. #Biotech #AllergyInnovation #Immunology #LifeSciences #FundingNews To view or add a comment, sign in Improvement of the therapeutic management of allergic patients in Europe An expert think tank's position paper on allergen immunotherapy To view or add a comment, sign in Yuhan Corporation's novel allergy drug lesigercept gains IND approval from MFDS for Phase 2 clinical trials - 12-week treatment for 150 patients with chronic spontaneous urticaria - Study to confirm safety, efficacy, and clinical benefits in an expanded patient cohort in Asia and Europe Yuhan Corporation announced on October 15 that it received approval from the Ministry of Food and Drug Safety (MFDS) on October 14 for its Phase 2 clinical trial plan (IND) for lesigercept (development code YH35324). Lesigercept is a novel anti-Immunoglobulin E (IgE) Fc fusion protein drug designed to alleviate allergic symptoms through a dual mechanism of action, by binding to and eliminating both free IgE and IgE receptor alpha (FcRI) autoantibodies present in the bloodstream

The question whether GABA forming microbiota can alter plasma GABA is unresolved: two germ-free models employing metabolomics support this premise (97, 98) whereas another germ-free rodent study did not (99)

Eur J Endocrinol 133 : 251254

Moreover, chronic stress exposure triggers systemic inflammatory activation through upregulation of pro-inflammatory cytokine cascades (Ravi et al., 2021)