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Although we successfully obtained the COP1-bound DDD complex, as judged by SDS-PAGE, the two largest populations were those without COP1 bound, suggesting that COP1 dissociates from the DDD complex

Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment directly influencing tumor cell growth, angiogenesis, and immune suppression

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All statistical analyses were performed using R version 4.1.1 (R Foundation for Statistical Computing)

doi:10.21203/rs.3.rs-18340/v1 11