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However, unlike those in bacteria and unicellular eukaryotes, PTS in mammals has not yet been clearly investigated [284]

Pinhasov A, Mandel S, Torchinsky A, Giladi E, Pittel Z, Goldsweig AM, et al

Its first intracellular step towards NAD + biosynthesis is its phosphorylation by nicotinamide riboside kinases (NRKs), forming NMN, which is then transformed to NAD + by NMNATs [13,40] (Figure 3)