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The published preclinical literature uses weight-adjusted rodent dosing that doesn't translate cleanly to fixed human protocols, so researchers extrapolate

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Data were expressed as permeability (Papp) calculated using the following formula: R e Papp ( B - A ) Papp ( A - B )

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Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer