does glutathione need to be made fresh

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"Micronutrients in HIV-Positive Persons Receiving Highly Active Antiretroviral Therapy." Am J Clin Nutr 85.2 (2007): 333-45

Passaia, G

187 Recently, we found that malic enzyme 1 (Me1) regulates ferroptosis in hepatic I/R-induced injury, and its inactivation further decreased the production of NADPH and failed to restore GSH synthesis, 188 suggesting that targeting Me1 may be a viable strategy for treating ferroptosis-related diseases by altering GSH synthesis