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However, our current testing shows you can go a lot further than that before encountering significant issues

Stock solutions (1 mM) were prepared in ultrapure water (Arium pro, Sartorius AG, Gottingen, Germany) and stored at 20 C

The signal-to-noise ratio for the hyperpolarised 13 C-pyruvuate (SNR Pyr ) was relatively high in the adjacent normal-appearing kidney (14.7), while it was 15.0 and 10.2 in the medial and lateral tumour regions, respectively

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The approach has been validated through extensive clinical research demonstrating that selectivity can be achieved without sacrificing efficacy for the targeted application