Therefore, targeting cellular oxidative stress through antioxidants has been suggested as a potential therapeutic option against neurological disorders, particularly using natural plant extracts
a number of other therapies may be of benefit for AIDS patients, for example combinations of GSH with the following drugs: cyclosporin A, thalidomide, pentoxifylline, selenium, desferroxamine, 2L-oxothiazolidine, 2L-oxothiazolidine-4-carboxylate, diethyldithiocarbamate (DDTC), BHA, nordihydroguairetic acid (NDGA), glucarate, EDTA, R-PIA, a-lipoic acid, quercetin, tannic acid, 2'-hydroxychalcone, 2-hydroxychalcone, flavones, a-angelicalactone, fraxetin, curcurmin, probucol, and arcanut (areca catechul)
Abbreviations ABHD17: /-hydrolase domain 17 ACSL4: Acyl-CoA synthetase family member 4 AMI: Acute myocardial infarction APT1: Palmitoyl acyl transferase 1 ARF6: ADP-ribosylation factor 6 ART: Artemisinin ATF4: Activating transcription factor 4 ATG2: Autophagy - related protein 2 2-BP: 2-bromopalmitate CRC: Colorectal cancer FPN: Iron exporter ferroportin FRDA: Friedreich ataxia GBM: Glioblastoma GC: Gastric cancer GPX4: Glutathione peroxidase 4 GSDMD: Gasdermin D GSSG: Glutathione disulfide GSH: Glutathione GSTP1: Glutathione S-Transferase Pi-1 HCC: Hepatocellular carcinoma HK1: Hexokinase 1 HSCs: Hepatic stellate cells KRAS: Kirsten rat sarcoma viral oncogene homolog LC3: Microtubule-associated protein 1 light chain 3 LDL: Lectin-like oxidized low-density lipoprotein LIP: Labile iron pool LOXs: Lipoxygenases NASH: Non-alcoholic steatohepatitis NBIA: Neurodegeneration with brain iron accumulation NOD2s-R444C: Pathogenic NOD2 short isoform variant NRAS: Neuroblastoma RAS viral oncogene homolog Nrf2: Nuclear factor erythroid 2-related factor 2 Panx2: Pannexin 2 PATs: Palmitoyltransferases PPAR: Peroxisome proliferator-activated receptor gamma PPT1: Palmitoyl protein thioesterase 1 PRDX6: Peroxiredoxin 6 PUFA: Polyunsaturated fatty acid ROS: Reactive oxygen species Scamp1: Secretory carrier membrane protein 1 SCIRI: Spinal cord ischemia-reperfusion injury SKCM: Skin cutaneous melanoma SLC7A11: Recombinant solute carrier family 7, member 11 STEAP1: Six-transmembrane epithelial antigen of the prostate 1 System Xc: Cystine-glutamate antiporter TFR1: Transferrin receptor 1 WIPI4: WD repeat domain phosphoinositide interacting 4 YTHDF3: YTH N6-Methyladenosine RNA Binding Protein F3 ZDHHC: Asp-His-His-Cys References Dixon SJ et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death
doi: 10.1016/j.expneurol.2004.09.008 79 TalM
Compared to traditional pharmaceuticals, this makes quality assurance more difficult
