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Several hours to days after CA, regions of the brain with high metabolic demandssuch as the hippocampus, white matter centers, and basal gangliaare among the first to sustain damage due to their critical reliance on adequate oxygen and blood supply

sometimes it points to a deeper issue

doi: 10.1016/j.fgb.2006.03.005

7.6.2 The linker-metal interface A significant problem in the creation of ID-ADCs pertains to the attachment site of the linker to the metal complex

mTOR signalling is involved in regulating differentiation and survival in neurons, as well as synaptic plasticity, learning and memory and food uptake in adult brain 15