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More recently, however, trials have investigated its use in conditioning regimens as a cytoreductive agent

One more thing, a bacteria can enter from there and may cause infection

HIF-1, directly upregulated by anoxia, is a targetable transcription factor

Cystine can be sequentially converted into GSH, which is indispensable in maintaining the intracellular redox balance as it can be utilized by GPX4 as a cofactor to alleviate lipid peroxidation (LPO) [32, 33] (Fig