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108110 Studies on non-obese diabetic (NOD) mice revealed increased activated intestinal CD4 + T cells, changes in TH1/TH2 intestinal cytokine ratios associated with activated dendritic and TH17 cells, increased natural killer cell cytotoxicity, and cytokine secretion of IFN- and IL-6

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Head Neck 35(6):794-9, 2013

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In M1 macrophages, a low ratio of -KG as a result of glutamine producing succinate can enhance their proinflammatory phenotype, which is beneficial for inhibiting the growth of tumor cells and enhancing their own immune function [24, 28] (Fig