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10.1016/j.ccell.2018.03.004 125 ToumiR.SamerA.SoufliI.RafaH.Touil-BoukoffaC

This is because B12 helps produce serotonin, a neurotransmitter that regulates mood and emotions

Conditions such as intestinal or stomach problems, poor nutrition, HIV, pregnancy, old age, veganism and alcoholism can contribute to vitamin B12 deficiency

They're considered to be weak, so they're usually given along with other types of diuretics

The synergy becomes clear: AOD-9604 mobilises fat, but that mobilisation is wasted if mitochondria lack the NAD+ cofactors required to oxidise fatty acids through beta-oxidation and the Krebs cycle