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Larbig, W., et al

This targeted NAD-specific metabolomics was developed in metabolomics facility of Finnish Institute for Molecular Medicine (FIMM) and recently published in Presterud et al 35

The depletion of glutathione due to coffee consumption may represent a critical pathway through which coffee influences myeloma risk. Recent Study Findings Its important to understand how coffee affects glutathione metabolism to assess its impact on multiple myeloma risk

PNAS USA 92:76907694 Zarka MH, Bridge WJ (2017) Oral administration of -glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study

Its worth noting that the proliferation status of non-senescent cells (quiescent/confluent or proliferating) also affected the metabolite ratio between senescent/non-senescent cells (Table 1