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While ROS originate from multiple sources, mitochondria are the largest contributors (Holmstrom and Finkel, 2014

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First-degree relatives of patients with non- HFE mutations should undergo testing

SLC7A11 knockdown prevents HCC growth (113)

Taken together, the results showed that Tim-AIII, by initiating G2/M-phase arrest, potently reduced cell proliferation and viability, even caused cell death in NSCLC cells