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Fatty degeneration occurs when too many fat molecules accumulate in the liver, which affects the assembly of VLDLs and inhibits the endogenous metabolic pathways of blood lipids

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Chen G, Chakravarti N, Aardalen K, Lazar AJ, Tetzlaff MT, Wubbenhorst B, Kim SB, Kopetz S , Ledoux AA, Gopal YN, Pereira CG, Deng W, Lee JS, Nathanson KL, Aldape KD, Prieto VG, Stuart D, Davies MA

For GI-receptor targeted prototypes, it is not clear how such a particle avoids surface premature binding from protein and lipids in the GI tract