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Its distinctive feature is a significant stimulation of appetite via the orexigenic ghrelin pathway, increasing circulating ghrelin levels

10.1021/tx950153d 24 GilletteM

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Annu Rev Pharmacol Toxicol 25:715744 Ke T, Sidoryk-Wegrzynowicz M, Pajarillo E, Rizor A, Soares FAA, Lee E, Aschner M (2019) Role of astrocytes in manganese neurotoxicity revisited