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Just as HOOH (hydrogen peroxide) is more oxidized than HOH (O in H 2 O 2 has an oxidation number of 1- while the O in H 2 O has an oxidation number of -2), RSSR is the oxidized form (S oxidation number -1), and RSH is the reduced form (S oxidation number -2) of thiols

Kanoski SE, Hayes MR, Skibicka KP

Recently heme and ferrylHb were identified as activators of the NLRP3 inflammasome leading to processing and secretion of active IL-1 in LPS-primed macrophages (81, 82)

In human gingival mesenchymal stem cells, Epitalon regulates gene expression and protein synthesis: it preferentially binds to histones H1/6 and H1/3 at sites that interact with DNA, thus suggesting that binding to histones may be an additional mechanism for enhancing the expression of genes that regulate neuronal differentiation and protein synthesis [10]