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Notably, the G/D-CuP group showed the lowest ratio of CD86-positive macrophages/CD206-positive macrophages, indicating an enhanced M1-to-M2 transition (Supplementary Fig

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The trial enrolled 300 obese subjects (BMI 27-35 kg/m) across multiple centers and randomized them to AOD-9604 (3 mg subcutaneous injection once or twice daily) or placebo for 12 weeks

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