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Upon oxysterol binding, these receptors act as transcription factors, promoting the expression of apolipoprotein E (ApoE), as well as ATP binding cassette subfamily members ABCA1 and ABCG1 [103, 104]

Aging disturbs this delicate balance through mechanisms including impaired epithelial turnover, immune senescence, and shifts in microbial populations that favor pro-oxidant species

Mitochondrial GSTs display both GSH transferase and peroxidase activities that detoxify harmful byproducts through GSH conjugation or GSH-mediated peroxide reduction ( Figure 3