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Low levels of these ion concentrations in the blood and heart cells can reduce the contractility of the heart and cause lethal arrhythmias and permanently damage the kidneys

Alugupalli et al., 2004)

For example, cystine availability in cancers is limited that the TSS pathway is activated to provide an alternative source of cysteine 16

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conversely, in multiple myeloma (MM), MDSCs induce tumor cell autophagy via AMPK phosphorylation, upregulating MCL-1/BCL-2 expression to enhance MM cell survival (111)