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Description

Encourages the formation of new connections between nerve cells by activating a protein (CREB) that switches on genes involved in learning and memory

Aug 2017;12(8):1287-1293

IL-18, another proinflammatory cytokine released when the NLRP3 inflammasome is activated, has been demonstrated to be correlated with susceptibility to sporadic late-onset AD (92,96)

Through AMPK-dependent phosphorylation, it prevents inflammasome assembly while simultaneously reducing mitochondrial ROSs, key upstream activators of NLRP3, by stabilizing the mitochondrial function through the partial inhibition of Complex I