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The type of neurological disorder that arises depends on (i) which locus ceruleus neurons are damaged, (ii) genetic variants that give rise to susceptibility to toxic metal uptake, cytotoxicity, or clearance, (iii) the age, frequency, and duration of toxicant exposure, and (iv) the uptake of various mixtures of toxic metals

As shown in Figure 5G, the number of common OTUs in the six groups was 523

Pediatrics 137(Suppl 2):S124S135

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Together, these intriguing findings demonstrate that RSL3 can effectively induce DNA damage, impair DNA damage repair response, and trigger autophagy in thyroid cancer cells by inhibiting GPX4