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In vitro, exo-si-c-Met was shown to promote apoptosis in chemoresistant but not isogenic chemosensitive cells

Thermo Fisher Scientific, Inc.) as described previously (20,21)

To unequivocally confirm the proposed structure of the ethyl ester of the tetradepsipeptide ( m/z 453.2576) and the octadepsipeptide ( m/z 837.4806), respectively, in a first set of experiments cell pellets of strain F3876/87 were extracted with MeOH or MeCN/H 2 O (70/30, v/v) instead of EtOH and the extract was analyzed for depsipeptide methyl esters as well as the free depsipeptides by UPLC-TOF MS