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Ayesh MH

112,113 Two MAT genes, MAT2A and MAT2B, are required for HSC activation

This would be especially true for drugs relying on a fine functional remodulation of a well preserved cellular system, like the NRF2 activators on the KEAP1-NRF2 system

Further studies will be required to refine the underlying mechanisms and to evaluate the broader physiological and pathological implications of these effects