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MCB-36 (0-10 M, 0-72 h) effectively degraded KRAS protein, decreased p-ERK levels and induced cell death in all cell lines tested including MIA PaCa-2 cells expressing KRAS G12C , KRAS G12C/Y96C , and KRAS G12C/H95D [1]

demonstrated that QE reversed the inhibition of transcription factor EB (TFEB) nuclear translocation incited by ethanol and exhibited similar effect to Torin 1 mTOR activity inhibitor) which could promote TFEB nuclear translocation, indicating that QE could alleviate chronic ethanol consumption induced liver injury and autophagic flux suppression by regulating mTOR-TFEB pathway (Li et al., 2019)

How many problems could be prevented if they knew they had the deficiency and could avoid triggers

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