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Dwane S, Durack E, Kiely PA

FIGURE 3 6.1.2 COX-2-PGE 2 -EP4 axis in RCC In most cell types, activated EP4 receptors are regulated by lipids and intracellular messengers such as cAMP (Fong et al., 2021) (Figure 3)

HNE reduces non-canonical inflammasome-mediated IL-1 release, but has no effect on GSDMD-mediated cell death Non-canonical inflammasome activation is dependent on caspase-11 (in mice) or caspase-4 (in humans) which directly bind with intracellular LPS (39, 40)

Lastly, most eye colourchanging materials and techniques are relatively new, so the longterm adverse effects or complications that may arise are not yet fully understood

2017;2:Cd009493