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Third, glutamine-derived glutathione synthesis avoids accumulation of deleterious ROS, allowing chondrocytes to survive in vascular growth plates ( In vitro studies have also shown that short-term inhibition of glycolysis suppresses the expression of matrix degeneration genes in chondrocytes and bovine cartilage explants cultured under inflammatory conditions ( RA is characterised by inflammation and destruction of bones and cartilage in the affected joints

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291 Furthermore, SIRT1 deacetylates and inhibits p53 in an NAD + -dependent manner, thereby downregulating downstream effectors such as p21 and proapoptotic factors (e.g., BAX and BCL2) to modulate cell fate with the consequence of antiaging and tumor-promoting effects

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