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Staresinic et al

Proper dose titration, starting at 0.25 mg weekly and increasing monthly, helps minimize these effects

Choline plays a role in lipid transport and metabolism, working synergetically with methionine and inositol

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278,279 Lifestyle interventions, particularly aerobic exercise, have also demonstrated benefits in enhancing mitochondrial biogenesis and function, offering a non-pharmacological approach to managing DPN (Fig