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*Correspondence: Igor Allaman, EPFL, SV/ Brain Mind Institute/LNDC, AAB 117, Station 19, CH-1015 Lausanne, Switzerland e-mail: [email protected] This article was submitted to Neuroenergetics, Nutrition and Brain Health, a section of the journal Frontiers in Neuroscience

Derived data supporting the findings of this study are available from the corresponding author [KI] on request

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Each patient undergoes a thorough consultation and assessment to determine the most appropriate therapy

through the non-oxidative phase, the synthesis of nucleotides will be supported by the provision of ribose-5-phosphate (to which external ribose can also contribute, if ribokinase is present)