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What is also very important, these processes increase intestinal permeability, enabling the translocation of microbial antigens and the activation of molecular pattern recognition receptors (TLRs and NODs) [139, 140]

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CDNA for the multidrug resistance (MDR-1) gene in a transcription unit of a safety modified retrovirus confers in vivo resistance to Taxol on early precursor cells in a mouse transplant model and on long-term human marrow culture