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With the development of imaging diagnosis technology, earlier and smaller breast cancers can be diagnosed early through advanced imaging tools, and the five-year survival rate of breast cancer has improved in the past decades [2, 3]

10.1101/cshperspect.a037895 29 ChaoY.ShangJ.JiW

Impaired Neuroplasticity: Suppression of hippocampal neurogenesis, reduced synaptogenesis, dendritic remodeling, and spine loss

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We next investigated whether mitochondria are the source of ROS generation in RPE cells upon GSH depletion, we used MitoSOX Red to detect mitochondrial ROS (Fig