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Human chondrocytes in vitro (Huang/Zhu et al., 2021) Selectively removed senescent cells from expanded human chondrocyte cultures, suggesting cartilage-repair relevance in a dish, not a person

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Disclosures: Takayuki Iwamoto: Nothing to Disclose, Yasutoshi Nozaki: Nothing to Disclose, Yoshiki Ito: Nothing to Disclose, Yuki Tahata: Nothing to Disclose, Hayato Hikita: Nothing to Disclose, Tetsuo Takehara: Nothing to Disclose, Hideki Hagiwara: Nothing to Disclose 473 SUSTAINED VIROLOGIC RESPONSE AND POSTTREATMENT LIVER FUNCTION ARE ASSOCIATED WITH 5-YEAR SURVIVAL AFTER DIRECT-ACTING ANTIVIRAL TREATMENT IN DECOMPENSATED CIRRHOTIC PATIENTS WITH HEPATITIS C VIRUS: A LONG-TERM FOLLOW UP STUDY OF JAPANESE CLINICAL TRIAL COHORT Yuki Tahata 1 Hayato Hikita 2 Akinobu Takaki 3 Masayuki Kurosaki 4 Kentaro Matsuura 5 Hiroshi Yatsuhashi 6 HIDEKATSU KURODA 7 Yoshiyuki Ueno 8 Takahiro Kodama 1 Ryotaro Sakamori 9 Tomohide Tatsumi 1 Tetsuo Takehara 1 , 1 Osaka University, 2 Osaka University Graduate School of Medicine, 3 Okayama University, 4 Musashino Red Cross Hospital, 5 Nagoya City University, 6 Nagasaki Medical Center, 7 Iwate Medical University, 8 Yamagata University, 9 Osaka National Hospital Background: Sustained virologic response (SVR) can be achieved in approximately 90% of decompensated cirrhotic patients with chronic hepatitis C virus (HCV) infection by direct-acting antiviral (DAA) treatment