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Before we consider this to be the case, we must rule out other causes, such as poor adherence to hygienic and dietary measures, a lack of treatment adherence, renal hypoperfusion due to excessive use of vasodilators, and the contribution of low cardiac output in patients with left ventricular dysfunction, who would benefit from, for example, inotropic agents

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Because both CMI and its active metabolite, DMI, have long elimination half-lives, the prescriber should take into consideration the fact that steady-state plasma levels may not be achieved until 2 to 3 weeks after dosage change ( seeCLINICAL PHARMACOLOGY)

Bredlau AL, Motamarry A, Chen C, McCrackin MA, Helke K, Armeson KE, Bynum K, Broome AM, Haemmerich D (2018) Localized delivery of therapeutic doxorubicin dose across the canine blood-brain barrier with hyperthermia and temperature sensitive liposomes