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Regul Pept 74: 97-103

ZDHHC5 knockdown inhibits NLRP3 oligomerization, NLRP3-NEK7 interactions, and the formation of intracellular ASC macroaggregates, reducing mices inflammatory response (74)

This allows oral megadoses (e.g., 1,000 g or more daily) to raise serum B levels even in individuals with pernicious anemia or low stomach acid