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Despite substantial weight loss, most obesity drugs such as Wegovy and Mounjaro do not meaningfully improve quality of life and few show cardiovascular benefits at one year, finds a new study in Comparing the Big 3, Semaglutide, Tirzepatide and Retatrutide : r Mounjaro CagriSema vs tirzepatide: which next generation weight loss treatment wins? SeekPeptides CagrilintideSemaglutide in Adults with Overweight or Obesity and Type 2 Diabetes New England Journal of Medicine Cagrilintide produced 10.8 percent body weight loss in 26 weeks in a phase 2 trial. Without touching the GLP 1 pathway. Different mechanism, different lever. Cagrilintide is a long acting amylin analog. Amylin is
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