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Relevant fractions were concentrated and then loaded on a gel filtration column, which was equilibrated by size-exclusion chromatography (SEC) buffer (50 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM MgCl 2 , and 0.5 mM tris(2-carboxyethyl)phosphine (TCEP))

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This creates a hollow sphere in which active substances such as curcumin are encapsulated

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( As illustrated by the comparison of voluntary and involuntary exercise above, implementation of neuroproteomic approaches in behavioral neuroscience research has led to the identification of task-dependent regulation of specific proteins

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