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A study also found that aging cells gradually accumulated in the visceral white adipose tissue and liver during aging, and the inflammatory cytokines secreted by aging cells (representing the senescence-associated secretory phenotype, SASP) induced macrophage proliferation and the expression of CD38 ( In vitro , it was found that lipopolysaccharide (LPS) in macrophages could upregulate the expression of CD38 in a time-and-dose-dependent manner