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Shikonin reverses cancer-associated fibroblast-induced gemcitabine resistance in pancreatic cancer cells by suppressing monocarboxylate transporter 4-mediated reverse Warburg effect

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This finding is of fundamental significance: it confirms that the paracrine mechanism, rather than direct cell replacement, is the primary route for the therapeutic efficacy of MSCs

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Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

It does have a defined role as a necessary micronutrient for leukocyte function and antioxidant activity, this being the only foundation as to why it should be used as a COVID-19 treatment option with little to no definitive clinical evidence to support this notion