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Furthermore, lymphovascular invasion is a critical step in tumor dissemination and a strong adverse prognostic factor for breast cancer survival [26]

Mori N, Yasutake A, Hirayama K (2007) Comparative study of activities in reactive oxygen species production/defense system in mitochondria of rat brain and liver, and their susceptibility to methylmercury toxicity

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As a result, therapeutic interventions targeting metabolic pathways, including antioxidants such as GSH, may require reassessment in light of these evolving definitions

These data suggest that NRF2 activation following GSH depletion causes repression of LXR activity, leading to lower expression of lipogenic enzymes and lower levels of serum triglycerides