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alpha-glucosidase) Competitive in addition of alpha-glucosidase reduces postprandial glucose rise (reduction: 30-50%) results in delayed carbohydrate absorption: starches, dextrins, maltose, sucrose (not lactose) Adverse Effects: most common: flatulence hypoglycemia may occur or give used in combination with insulin or sulfonylureas Drug-drug interaction: acarbose interferes with metformin absorption Miglitol (Glyset) similar to acarbose (Precose) but possibly with less hepatotoxicity Acarbose (Precose) and miglitol (Glyset) have similar similar gastrointestinal effects Thiazolidinedione Derivatives Troglitazone (Rezulin)-- FDA approved for insulin resistant patients who are receiving insulin REMOVED FROM U.S

Claudins, particularly Claudin-5, are critical components of intercellular TJs and play a significant role in regulating the integrity and permeability of the BBB [96]