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AOD-9604 Does Not Function Like: Stimulants Beta-agonists Dopamine-modulating drugs Sympathomimetics There is no evidence of receptor downregulation with continuous AOD-9604 use in published studies

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COMT inhibitors (COMT-I) can rebalance this abnormal metabolic loop by suppressing the overproduction of SAH by COMT after LDopa administration and lowering Hcy levels (Cossu et al