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Rather surprisingly, this suggests that the benefits of reduced mTORC1 signaling, and increased autophagy may be mediated primarily by an A-independent mechanism and moreover, previous studies have demonstrated that mTORC1 inhibition leads to the suppression of tauopathy 65,66

doi: 10.11604/pamj.supp.2020.35.2.22877 36 BhatSASinghNTrivediAKansalPGuptaPKumarA

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Biomedicines 10 , 125 (2022)

A dose-dependent effect has also been observed, with a 7% increase in the overall risk of death for every five pack-years increase in smoking history [113]