To improve the pharmacological properties and enable tumor-selectivity, the phenylazopyridine ligand was terminally functionalized with a hydroxy group that could be used for further chemical modifications

B12 has many functions in our body, so unfortunately a deficiency will give rise to a wide variety of symptoms, like brain fog, memory problems, cognitive impairment, insomnia, headaches, especially migraine, behavioural changes, learning problems, nominal aphasia, mood swings, irritability, depression, anxiety, hallucinations, delusions, psychosis, peripheral paraesthesia (pins and needles), numbness, neuropathic pains, poor balance, reduced vibration sense or proprioception (joint position sense), tinnitus, ataxia, taste impairment, sometimes myelopathy, fatigue, anaemia (either with larger red blood cells, or with normal size of the red blood cells when there is also iron deficiency), other reduction in blood cells, abdominal complaints, malabsorption, failure to thrive, weight loss, diarrhoea, hyperpigmentation, glossitis, (aphthous) stomatitis, infertility, urinary tract infections, joint and muscle pain, muscle weakness, spasticity, seizures, cardiomyopathy, urinary and/or faecal incontinence, postural hypotension/dizziness, erectile dysfunction, to name a few

While extreme doses could theoretically lighten pigment, standard wellness routines use glutathione to combat the oxidative stress that leads to premature signs of aging
Don Buford, MD founded Texas Orthobiologics as a clinic where patients can get an unbiased orthopedic diagnosis and a complete discussion of their non-surgical and surgical treatment options including orthobiologics or orthopedic surgery
It can even improve blood flow and collagen formation to help restore ligaments and bone-to-tendon injury