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Under the ROS stimulation, the thin-sophisticated moiety (-SH) of cysteine residues is oxidized to form reversible intramolecular disulfide bonds (R-S-S-R) and sulfinyl groups (R-SOH), or irreversible sulfinic acids (R-SO 2 H) and sulfonic acids (R-SO 3 H) ( As we mentioned earlier, GPX7 does not contain domains bound to GSH, so it cannot participate in redox reactions with GSH as a substrate like other GPX family members

Nevertheless, if drugs inhibit ThDP-dependent enzymes, as, e.g., omeprazole does (157), direct exposure of the gastrointestinal system to oral drugs may increase its vulnerability compared to other tissues

Ferritinophagy mediated by NCOA4 promotes ferritin degradation and iron release, thereby increasing free iron content and further inducing ferroptosis [97]